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Trusted, medically reviewed health information • Not a substitute for medical advice
Important: The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Generic Name: Topiramate
You experience severe allergic reaction symptoms (swelling of the face, lips, tongue, or throat causing difficulty breathing), severe rash with skin peeling, sudden intense chest pain, or symptoms of overdose. Call emergency medical services immediately.
Treatment of epilepsy, prevention of migraine
Seizures (partial onset, primary generalized tonic-clonic), Migraine prophylaxis
Epilepsy: 400 mg/day in two divided doses. Migraine: 100 mg/day in two divided doses.
Varies by weight and indication
Base dose on renal function
400 mg/day (epilepsy)
Reduce dose by 50% if CrCl < 70 mL/min
Use with caution, clearance may be decreased
Paresthesia, anorexia, weight loss, cognitive impairment, fatigue
Acute myopia and secondary angle closure glaucoma, metabolic acidosis, kidney stones
Recent alcohol use within 6 hours (Trokendi XR only)
Risk of oligohidrosis and hyperthermia, suicidal behavior and ideation
Phenytoin, carbamazepine, valproic acid, oral contraceptives (decreases efficacy)
Can be taken with or without food
Increases CNS depression; avoid with extended-release forms
Increased risk of cleft lip/palate
Excreted in milk, monitor infant for diarrhea/somnolence
Drink plenty of fluids to prevent kidney stones. May impair cognitive function. Use non-hormonal contraception.
Take as soon as remembered if within 6 hours, otherwise skip.
Serum bicarbonate, renal function, intraocular pressure if symptoms arise
Content for Topiramate was synthesized and fact-checked against standardized regulatory monographs, official pharmacopoeias, and national health authorities:
The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.