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Trusted, medically reviewed health information • Not a substitute for medical advice
Important: The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Generic Name: Tizanidine
You experience severe allergic reaction symptoms (swelling of the face, lips, tongue, or throat causing difficulty breathing), severe rash with skin peeling, sudden intense chest pain, or symptoms of overdose. Call emergency medical services immediately.
Management of spasticity
Muscle spasticity (e.g., from multiple sclerosis or spinal cord injury)
2 mg every 6 to 8 hours initially, titrate up to 8-24 mg/day
Safety and efficacy not established
Start low and titrate slowly
36 mg/day
Use with caution in CrCl < 25 mL/min; reduce dose
Avoid or use with extreme caution in hepatic impairment
Dry mouth, somnolence, asthenia, dizziness
Hepatotoxicity, hypotension, hallucinations
Concomitant use with ciprofloxacin or fluvoxamine
Hypotension risk, liver injury, withdrawal with abrupt discontinuation
CYP1A2 inhibitors (ciprofloxacin, fluvoxamine), other CNS depressants
Food alters pharmacokinetics differently for tablet vs capsule
Increases CNS depression
Use only if benefit justifies potential risk
Not recommended
May cause drowsiness or dizziness. Do not abruptly stop taking. Be consistent regarding taking with or without food.
Skip the missed dose and resume normal schedule.
Blood pressure, liver function tests at baseline and periodically
Content for Tizanidine was synthesized and fact-checked against standardized regulatory monographs, official pharmacopoeias, and national health authorities:
The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.