Promethazine
Generic Name: Promethazine
Seek Urgent Medical Attention If:
You experience severe allergic reaction symptoms (swelling of the face, lips, tongue, or throat causing difficulty breathing), severe rash with skin peeling, sudden intense chest pain, or symptoms of overdose. Call emergency medical services immediately.
Uses & Medical Indications
Treatment of allergic conditions, motion sickness, nausea and vomiting
Nausea/Vomiting, Motion Sickness, Allergic Rhinitis, Sedation
Dosage & Administration Guidelines
12.5-25 mg every 4-6 hours PRN
0.25-1 mg/kg every 4-6 hours PRN (Children >= 2 years)
Start at lower doses due to anticholinergic effects
100 mg/day
No specific adjustment required
Use with caution in hepatic impairment
Side Effects & Safety Warnings
Drowsiness, dry mouth, blurred vision, dizziness
Respiratory depression, extrapyramidal symptoms, neuroleptic malignant syndrome
Children < 2 years, coma, treatment of lower respiratory tract symptoms
Black box warning: Fatal respiratory depression in children < 2 years
Interactions (Drugs, Food & Alcohol)
CNS depressants, anticholinergics, MAOIs
N/A
Increases CNS depression significantly
Pregnancy & Breastfeeding Safety
Use if potential benefit justifies risk; avoid near term
Use caution; may inhibit lactation or cause sedation in infant
Patient Counseling & Practical Advice
Causes extreme drowsiness. Do not drive. Avoid alcohol.
Take as soon as remembered if needed. Skip if near next dose.
Respiratory rate, mental status, anticholinergic effects
Content for Promethazine was synthesized and fact-checked against standardized regulatory monographs, official pharmacopoeias, and national health authorities:
- Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
- World Health Organization (WHO) — Model List of Essential Medicines 23rd List
- Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
- National Health Service (NHS) — Medicines A to Z Clinical Guidelines
The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.