Ondansetron
Generic Name: Ondansetron
Seek Urgent Medical Attention If:
You experience severe allergic reaction symptoms (swelling of the face, lips, tongue, or throat causing difficulty breathing), severe rash with skin peeling, sudden intense chest pain, or symptoms of overdose. Call emergency medical services immediately.
Uses & Medical Indications
Prevention of nausea and vomiting associated with chemotherapy, radiation, or surgery
Chemotherapy-Induced Nausea/Vomiting (CINV), Postoperative Nausea/Vomiting (PONV)
Dosage & Administration Guidelines
8 mg twice daily or 8-16 mg 30 mins before chemotherapy
0.15 mg/kg IV or weight-based oral dosing
Same as adult
24 mg/day orally; 16 mg/dose IV
No adjustment necessary
Maximum 8 mg/day in severe hepatic impairment
Side Effects & Safety Warnings
Headache, constipation, diarrhea, dizziness, fatigue
QT prolongation, serotonin syndrome, severe hypersensitivity
Use with apomorphine
Dose-dependent QT prolongation; avoid in congenital long QT syndrome
Interactions (Drugs, Food & Alcohol)
Apomorphine, QT-prolonging drugs (amiodarone, macrolides), serotonergic agents
N/A
No specific interaction
Pregnancy & Breastfeeding Safety
Often used off-label for morning sickness; generally considered safe but consult OB/GYN
Use caution; excretion in milk is likely
Patient Counseling & Practical Advice
Let ODT dissolve on tongue. Drink fluids if constipated.
Take as soon as remembered if nauseous. Otherwise, skip.
ECG (in high-risk patients), potassium, magnesium
Content for Ondansetron was synthesized and fact-checked against standardized regulatory monographs, official pharmacopoeias, and national health authorities:
- Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
- World Health Organization (WHO) — Model List of Essential Medicines 23rd List
- Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
- National Health Service (NHS) — Medicines A to Z Clinical Guidelines
The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.