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Trusted, medically reviewed health information • Not a substitute for medical advice
Important: The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Generic Name: Sitagliptin
You experience severe allergic reaction symptoms (swelling of the face, lips, tongue, or throat causing difficulty breathing), severe rash with skin peeling, sudden intense chest pain, or symptoms of overdose. Call emergency medical services immediately.
Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Type 2 Diabetes Mellitus
100 mg orally once daily with or without food.
Safety and effectiveness not established in pediatric patients under 18.
Dose based on renal function.
100 mg daily.
eGFR 30 to <45: 50 mg daily. eGFR <30: 25 mg daily.
No dose adjustment for mild to moderate hepatic impairment.
Upper respiratory tract infection, nasopharyngitis, headache.
Pancreatitis, severe arthralgia, bullous pemphigoid, heart failure.
History of serious hypersensitivity reaction to sitagliptin.
Risk of acute pancreatitis; monitor for persistent severe abdominal pain.
Digoxin (slight increase in digoxin concentrations), insulin/sulfonylureas (increased hypoglycemia risk).
None significant.
Limit alcohol consumption to avoid hypoglycemia.
Use during pregnancy only if clearly needed.
Caution advised; unknown if excreted in human milk.
Report severe persistent stomach pain immediately.
Take as soon as remembered. Do not double up doses.
HbA1c, renal function, signs/symptoms of pancreatitis.
Content for Januvia was synthesized and fact-checked against standardized regulatory monographs, official pharmacopoeias, and national health authorities:
The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.