Trusted, medically reviewed health information • Not a substitute for medical advice
Medically Verified MonographSchedule IIClass: Opioid Analgesic

Hydrocodone

Generic Name: Hydrocodone

Common Brand Names: Hysingla ER, Zohydro ER
Dosage Form:Tablet ER, Capsule ER
Route:Oral
Pregnancy Category:C
Last Reviewed:9/21/2026

Seek Urgent Medical Attention If:

You experience severe allergic reaction symptoms (swelling of the face, lips, tongue, or throat causing difficulty breathing), severe rash with skin peeling, sudden intense chest pain, or symptoms of overdose. Call emergency medical services immediately.

Uses & Medical Indications

Severe pain

Medical Conditions Treated:

Chronic pain requiring daily around-the-clock opioids

Dosage & Administration Guidelines

Adult Dosage

20 mg once daily (ER)

Pediatric Dosage

Not recommended

Elderly / Geriatric Considerations

Start at lower dose

Maximum Dose Limit

Varies by tolerance

Renal Impairment:

Start at 50% of normal dose

Hepatic Impairment:

Start at lower dose

Side Effects & Safety Warnings

Common Side Effects

Constipation, nausea, somnolence

Serious Adverse Reactions

Respiratory depression, addiction

Contraindications:

Significant respiratory depression, paralytic ileus

Important Warnings & Precautions:

Risk of addiction, abuse, and misuse

Interactions (Drugs, Food & Alcohol)

Drug-Drug Interactions:

Benzodiazepines, CNS depressants, CYP3A4 inhibitors

Food & Dietary Interactions:

N/A

Alcohol Interaction Warning:

Avoid, fatal respiratory depression

Pregnancy & Breastfeeding Safety

Pregnancy Safety

Risk of neonatal opioid withdrawal syndrome

Breastfeeding / Lactation

Avoid

Patient Counseling & Practical Advice

How to Take:

Swallow whole, do not crush or chew ER forms

What to Do if You Miss a Dose:

Skip missed dose and take next at regular time

Recommended Monitoring & Lab Tests:

Pain relief, respiratory status, bowel function

Related Medicines in Opioid Analgesic

Trustworthy Sources & Medical Review

Content for Hydrocodone was synthesized and fact-checked against standardized regulatory monographs, official pharmacopoeias, and national health authorities:

  • Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
  • World Health Organization (WHO) — Model List of Essential Medicines 23rd List
  • Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
  • National Health Service (NHS) — Medicines A to Z Clinical Guidelines
Reviewer Credentials: PharmD, Clinical PharmacologistLast Reviewed Date: 9/21/2026

The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.